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Department of Health and Human Services, National Institutes of Health

Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

Who can apply

  • Private colleges and universities
  • Nonprofits with 501(c)(3) status
  • Federally recognized tribal governments
  • Public and tribal housing authorities
  • Special district governments
  • Independent school districts
  • For-profit organizations (not small businesses)
  • County governments
  • State governments
  • Nonprofits without 501(c)(3) status
  • Tribal organizations
  • Others (see eligibility details)
  • City or township governments
  • Public and state-controlled colleges
  • Small businesses

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

About this grant

The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.

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