Department of Health and Human Services, National Institutes of Health

Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required)

Who can apply

  • Special district governments
  • Federally recognized tribal governments
  • Tribal organizations
  • Others (see eligibility details)
  • Independent school districts
  • Nonprofits without 501(c)(3) status
  • For-profit organizations (not small businesses)
  • County governments
  • Public and state-controlled colleges
  • Private colleges and universities
  • State governments
  • Public and tribal housing authorities
  • Nonprofits with 501(c)(3) status
  • Small businesses
  • City or township governments

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

About this grant

This R61/R33 concept complements NIMHs suite of clinical trial NOFOs by supporting feasibility and infrastructure development (R61) followed by well-powered clinical trials (R33) to test the effectiveness of system interventions and strategies for improving the organization, delivery, coordination, and clinical and functional outcomes of mental health services. System interventions - which may span, for example, structural, policy, organizational, and interpersonal domains - attend to issues about the access, equity, engagement/utilization, value (cost/financing), management, or quality and safety of mental health services, with the goal of improved care processes and clinical and functional outcomes. Accordingly, the focus of system interventions may include a variety of care settings, such as health systems and organizations, mental health and community clinics, schools, and child welfare or juvenile justice systems

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