Department of Health and Human Services, National Institutes of Health
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
Who can apply
- Public and tribal housing authorities
- For-profit organizations (not small businesses)
- City or township governments
- Independent school districts
- Federally recognized tribal governments
- Nonprofits without 501(c)(3) status
- County governments
- Tribal organizations
- Private colleges and universities
- Others (see eligibility details)
- Nonprofits with 501(c)(3) status
- Small businesses
- State governments
- Special district governments
- Public and state-controlled colleges
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
About this grant
The purpose of this Notice of Funding Opportunity (NOFO) is to support the preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics for the treatment of pain. The goal of the program is to accelerate the advancement of promising early-stage therapeutic candidates and facilitate their readiness for Phase II clinical trials. Applicants must have a promising small molecule or biologic lead candidate for optimization, a strong biological rationale for the proposed approach, and established assays to guide the optimization process. The scope of the program includes lead optimization, early-stage development activities, IND-enabling studies, development of pharmacodynamic and/or target engagement biomarkers, preparation and submission of an Investigational New Drug (IND) application, and Phase I clinical testing. This is a milestone-driven, phased cooperative agreement program that involves active participation by NIH program staff in project planning and ongoing monitoring of research progress.
Program history
- Past rounds of this program (93.213)
- Past rounds of this program (93.233)
- Past rounds of this program (93.273)
- Past rounds of this program (93.279)
- Past rounds of this program (93.395)
- Past rounds of this program (93.837)
- Past rounds of this program (93.838)
- Past rounds of this program (93.839)
- Past rounds of this program (93.840)
- Past rounds of this program (93.846)
- Past rounds of this program (93.853)
- Past rounds of this program (93.865)
- Past rounds of this program (93.866)
- Past rounds of this program (93.867)
Topics
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