Grants due in January 2027

66 open grants close in January 2027, 36 of them open to small businesses. Every listing links to its official source.

January 2027

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Friday, January 1 1 deadline

ERDC Broad Agency Announcement

Department of Defense Up to $1000M Small businesses eligible

Closes Jan 1, 2027

Monday, January 4 1 deadline

National Parks Business Plan Internship

Department of the Interior Up to $1.7M Nonprofits eligible

Closes Jan 4, 2027

Thursday, January 7 14 deadlines

Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)

Department of Health and Human Services Up to $375K Private colleges and universities

Closes Jan 7, 2027
Academic-Industrial Partnerships (AIP) to Translate and Validate In Vivo Imaging Systems (R01 Clinical Trial Optional)

Department of Health and Human Services Up to $500K Small businesses eligible

Closes Jan 7, 2027
Accelerating Solutions to Improve Access and Quality of Empirically-Supported Practices for Youth Mental Health (R01 Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2027
Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2027
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2027
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2027
Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2027
Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2027
Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2027
Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R21 Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2027
National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required)

Department of Health and Human Services Up to $500K Small businesses eligible

Closes Jan 7, 2027
Personal Health Informatics for Delivering Actionable Insights to Individuals (R01 Clinical Trial Optional)

Department of Health and Human Services Up to $250K Small businesses eligible

Closes Jan 7, 2027
Population Approaches to Reducing Alcohol-related Cancer Risk (R01 Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2027
Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R34 Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2027

Monday, January 11 5 deadlines

Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Jan 11, 2027
Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required)

Department of Health and Human Services Up to $700K Small businesses eligible

Closes Jan 11, 2027
Oceanographic Facilities and Equipment Support

U.S. National Science Foundation $5,000 to $47.5M Others (see eligibility details)

Closes Jan 11, 2027
Title X Family Planning Services Grants

Department of Health and Human Services $200K to $22M Nonprofits eligible

Closes Jan 11, 2027
Tribal Colleges and Universities Program (TCUP)

U.S. National Science Foundation $100K to $3.5M Others (see eligibility details)

Closes Jan 11, 2027

Tuesday, January 12 1 deadline

Genesis Mission Graduate Fellowship Pilot

Department of Energy - Office of Science Up to $20M Public and state-controlled colleges

Closes Jan 12, 2027

Wednesday, January 13 3 deadlines

Fiscal Year (FY) 2027 AmeriCorps State and National Competitive Grants

AmeriCorps Nonprofits eligible

Closes Jan 13, 2027
National Digital Newspaper Program

National Endowment for the Humanities $1 to $325K Nonprofits eligible

Closes Jan 13, 2027
Young Faculty Award (YFA) 2027

Department of Defense Others (see eligibility details)

Closes Jan 13, 2027

Thursday, January 14 1 deadline

Human Networks and Data Science (HNDS)

U.S. National Science Foundation $10K to $1.2M Small businesses eligible

Closes Jan 14, 2027

Friday, January 15 10 deadlines

Antarctic Research Not Requiring U.S. Antarctic Program (USAP) Field Support

U.S. National Science Foundation Others (see eligibility details)

Closes Jan 15, 2027
Arctic Research Opportunities

U.S. National Science Foundation From $330K Others (see eligibility details)

Closes Jan 15, 2027
Cultural Anthropology Program Senior Research Awards (CA-SR)

U.S. National Science Foundation Others (see eligibility details)

Closes Jan 15, 2027
F26AS00088 Endangered Species Conservation – Wolf Livestock Loss Compensation and Prevention

Department of the Interior $10K to $675K Federally recognized tribal governments

Closes Jan 15, 2027
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)

Department of Health and Human Services Up to $350K Small businesses eligible

Closes Jan 15, 2027
Human-Environment and Geographical Sciences Program (HEGS)

U.S. National Science Foundation Others (see eligibility details)

Closes Jan 15, 2027
Linguistics

U.S. National Science Foundation Small businesses eligible

Closes Jan 15, 2027
NOI: PROSPECT Program: Providing Opportunities for Specialized Education in Critical Technologies

Department of Energy Up to $1 Small businesses eligible

Closes Jan 15, 2027
ROSES 2025: A.18 Geosphere

National Aeronautics and Space Administration Others (see eligibility details)

Closes Jan 15, 2027
Social Psychology

U.S. National Science Foundation Small businesses eligible

Closes Jan 15, 2027

Tuesday, January 19 2 deadlines

Decision, Risk and Management Sciences (DRMS)

U.S. National Science Foundation Small businesses eligible

Closes Jan 19, 2027
Research on the Science and Technology Enterprise: Indicators, Statistics, and Methods (NCSES S&T)

U.S. National Science Foundation Others (see eligibility details)

Closes Jan 19, 2027

Wednesday, January 20 2 deadlines

Cybersecurity Innovation for Cyberinfrastructure (CICI)

U.S. National Science Foundation Up to $1.2M Others (see eligibility details)

Closes Jan 20, 2027
Improving Undergraduate STEM Education: Directorate for STEM Education (IUSE: EDU)

U.S. National Science Foundation $200K to $2M Small businesses eligible

Closes Jan 20, 2027

Thursday, January 21 1 deadline

Training-based Workforce Development for Advanced Cyberinfrastructure

U.S. National Science Foundation Up to $1M Others (see eligibility details)

Closes Jan 21, 2027

Friday, January 22 2 deadlines

2026 Diesel Emissions Reduction Act (DERA) National Program

Environmental Protection Agency Up to $12M Others (see eligibility details)

Closes Jan 22, 2027
National Bycatch Reduction Engineering Program (BREP) - FY2026/27

Department of Commerce $50K to $400K Small businesses eligible

Closes Jan 22, 2027

Monday, January 25 6 deadlines

Cancer Advancement through Partnerships in Research and Infrastructure (CAPRI) (U54 Clinical Trial Optional)

Department of Health and Human Services Nonprofits eligible

Closes Jan 25, 2027
Medical Scientist Training Program (MSTP) (T32)

Department of Health and Human Services Small businesses eligible

Closes Jan 25, 2027
ROSS Rapid Response Program

Department of Housing and Urban Development $113K to $250K Nonprofits eligible

Closes Jan 25, 2027
Security, Privacy, and Trust in Cyberspace (NSF SaTC)

U.S. National Science Foundation $50K to $1.2M Others (see eligibility details)

Closes Jan 25, 2027
Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) Program (UE5/T32)

Department of Health and Human Services Others (see eligibility details)

Closes Jan 25, 2027
Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) Program (UE5/T34)

Department of Health and Human Services Public and state-controlled colleges

Closes Jan 25, 2027

Tuesday, January 26 4 deadlines

EPSCoR Research Infrastructure Improvement Program: Focused EPSCoR Collaborations (FEC)

U.S. National Science Foundation $1M to $1.5M Others (see eligibility details)

Closes Jan 26, 2027
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Jan 26, 2027
HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)

Department of Health and Human Services Small businesses eligible

Closes Jan 26, 2027
National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Jan 26, 2027

Wednesday, January 27 4 deadlines

Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)

Department of Health and Human Services Up to $500K Nonprofits eligible

Closes Jan 27, 2027
Diabetes Research Centers (P30 Clinical Trial Optional)

Department of Health and Human Services Up to $1M Small businesses eligible

Closes Jan 27, 2027
Specialized Alcohol Research Centers (P50 Clinical trial Optional)

Department of Health and Human Services Up to $1.1M Small businesses eligible

Closes Jan 27, 2027
Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) (R24 - Clinical Trial Not Allowed)

Department of Health and Human Services Federally recognized tribal governments

Closes Jan 27, 2027

Thursday, January 28 4 deadlines

BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)

Department of Health and Human Services Up to $750K Small businesses eligible

Closes Jan 28, 2027
Methodology, Measurement, and Statistics (MMS)

U.S. National Science Foundation Others (see eligibility details)

Closes Jan 28, 2027
ROSES 2025: A.17 Hydrosphere

National Aeronautics and Space Administration Others (see eligibility details)

Closes Jan 28, 2027
Translational Neural Devices (R61/R33 - Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Jan 28, 2027

Friday, January 29 3 deadlines

Immune Tolerance Network (UM1 Clinical Trial Required)

Department of Health and Human Services Small businesses eligible

Closes Jan 29, 2027
Minor Use Minor Species Development of Drugs (R01)

Department of Health and Human Services Up to $250K Small businesses eligible

Closes Jan 29, 2027
Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Jan 29, 2027

Sunday, January 31 2 deadlines

Agriculture Innovation Center Grant Program

Department of Agriculture $600K to $1M Small businesses eligible

Closes Jan 31, 2027
Training and Employment Guidance Letter (02-26) for FY 2026 Community Project Funding/Congressionally Directed Spending

Department of Labor $50K to $5.3M Others (see eligibility details)

Closes Jan 31, 2027