Department of Health and Human Services, National Institutes of Health

Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)

Who can apply

  • Public and state-controlled colleges
  • Private colleges and universities
  • Federally recognized tribal governments
  • Tribal organizations
  • Public and tribal housing authorities
  • Nonprofits with 501(c)(3) status
  • City or township governments
  • Special district governments
  • Others (see eligibility details)
  • State governments
  • County governments
  • Nonprofits without 501(c)(3) status
  • Independent school districts
  • Small businesses
  • For-profit organizations (not small businesses)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

About this grant

The goal of this NOFO is to support R21 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets

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