Government grants for small business

787 grants for small businesses from government funders are open right now. The next deadline is Monday, Oct 26. 293 grants are coming up.

These federal, state and local grants list small businesses among eligible applicants. Check the project, location and operating-history requirements.

Due in November 2027

Apply by Nov 16, 2027

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $100K
Open
Apply by Nov 16, 2027

Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Nov 18, 2027

Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $300K
Open

Due in December 2027

Apply by Dec 3, 2027

Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Dec 3, 2027

Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Dec 23, 2027

Catalyze Product Definition Medical Device prototype design/testing and disease target identification and assay development (R61/R33 - Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Dec 23, 2027

Catalyze: Enabling Technologies and Transformative Platforms for HLBS Research (R33 - Clinical Trials Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $350K
Open
Apply by Dec 23, 2027

Catalyze: Product Definition for Small Molecules, Biologics and Combination Products - Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Dec 23, 2027

Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products - Preliminary Product/Lead Series Identification and Combination Product Prototype (R33 - Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Dec 23, 2027

Catalyze: Product Definition Medical Device Prototype Optimization (R33 - Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open

Due in January 2028

Apply by Jan 6, 2028

Continuation or Revision of NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UH3 Clinical Trial Required)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Jan 6, 2028

NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $500K
Open
Apply by Jan 6, 2028

NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Jan 6, 2028

Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Jan 7, 2028

Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $499K
Open
Apply by Jan 7, 2028

Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Optional)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $499K
Open
Apply by Jan 7, 2028

Advancing Healthcare for Older Adults from Populations that Experience Health Disparities (R01 - Clinical Trial Optional)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Jan 7, 2028

Basic Research in Cancer Health Disparities (R01 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Jan 7, 2028

Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Jan 7, 2028

Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $200K
Open

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Government grants for small business

Due in November 2027

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)

Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)

Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)

Due in December 2027

Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)

Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)

Catalyze Product Definition Medical Device prototype design/testing and disease target identification and assay development (R61/R33 - Clinical Trial Not Allowed)

Catalyze: Enabling Technologies and Transformative Platforms for HLBS Research (R33 - Clinical Trials Not Allowed)

Catalyze: Product Definition for Small Molecules, Biologics and Combination Products - Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed)

Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products - Preliminary Product/Lead Series Identification and Combination Product Prototype (R33 - Clinical Trial Not Allowed)

Catalyze: Product Definition Medical Device Prototype Optimization (R33 - Clinical Trial Not Allowed)

Due in January 2028

Continuation or Revision of NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UH3 Clinical Trial Required)

NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)

Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Not Allowed)

Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Optional)

Advancing Healthcare for Older Adults from Populations that Experience Health Disparities (R01 - Clinical Trial Optional)

Basic Research in Cancer Health Disparities (R01 Clinical Trial Not Allowed)

Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)

Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)

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