Government grants for small business

787 grants for small businesses from government funders are open right now. The next deadline is Monday, Oct 26. 293 grants are coming up.

These federal, state and local grants list small businesses among eligible applicants. Check the project, location and operating-history requirements.

Due in February 2027

Apply by Feb 10, 2027

Science of Learning and Augmented Intelligence (SL)

U.S. National Science Foundation

Applicants: Schools and colleges, For-profit companies, Individuals, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

From $550
Open
Apply by Feb 10, 2027

Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $750K
Open
Apply by Feb 11, 2027

Accelerating Research and Development of Next Generation Vaccines against Malaria - a Model for Mosquito-Borne Diseases (R61/R33 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Feb 11, 2027

BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $700K
Open
Apply by Feb 11, 2027

NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Feb 11, 2027

NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI (T15 Independent Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

$500K to $775K
Open
Apply by Feb 14, 2027

Advancing Global Health

Department of State

Applicants: Schools and colleges, For-profit companies, Individuals, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

$500K to $250M
Open
Apply by Feb 26, 2027

Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open

Due in March 2027

Apply by Mar 1, 2027

Accelerating Discovery through Partnered Research with All of Us to Analyze Participant Biospecimens (X01 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Mar 4, 2027

NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Mar 5, 2027

Coordinating Center for National Resource Network for the Study of Human Auditory and Vestibular Disorders (U24 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $200K
Open
Apply by Mar 5, 2027

Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Mar 5, 2027

High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $1.5M
Open
Apply by Mar 6, 2027

High Priority HIV and Substance Use Research (R01 Clinical Trial Optional)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Mar 6, 2027

Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $500K
Open
Apply by Mar 6, 2027

Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Mar 10, 2027

Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Up to $500K
Open
Apply by Mar 16, 2027

Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Mar 16, 2027

NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)

Department of Health and Human Services

Applicants: Schools and colleges, For-profit companies, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

Open
Apply by Mar 17, 2027

Deployed Warfighter Protection FY27

Department of Defense

Applicants: Schools and colleges, For-profit companies, Individuals, Local governments, Nonprofits, Small businesses, State governments, Tribal governments and organizations

Nationwide

$20K to $1.1M
Open

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Government grants for small business

Due in February 2027

Science of Learning and Augmented Intelligence (SL)

Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)

Accelerating Research and Development of Next Generation Vaccines against Malaria - a Model for Mosquito-Borne Diseases (R61/R33 Clinical Trial Not Allowed)

BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)

NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed)

NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI (T15 Independent Clinical Trial Not Allowed)

Advancing Global Health

Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)

Due in March 2027

Accelerating Discovery through Partnered Research with All of Us to Analyze Participant Biospecimens (X01 Clinical Trial Not Allowed)

NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

Coordinating Center for National Resource Network for the Study of Human Auditory and Vestibular Disorders (U24 Clinical Trial Not Allowed)

Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

High Priority HIV and Substance Use Research (R01 Clinical Trial Optional)

Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)

Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)

Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required)

NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)

Deployed Warfighter Protection FY27

Grant deadline reminders

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